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Target
Pantetheinase [22-493]
Ligand
BDBM510535
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
7.30±n/a nM
Citation
 Fleck, MT; Godbout, C; Koolman, HF Heteroaromatic compounds as Vanin inhibitors US Patent  US11078182 Publication Date 8/3/2021 
Target
Name:
Pantetheinase [22-493]
Synonyms:
Pantetheinase (VNN1)(22-493) | VNN1 | VNN1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52490.93
Organism:
Homo sapiens (Human)
Description:
aa 22-493
Residue:
472
Sequence:
QDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDILEGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPVQERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQNLFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMNVLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLLLSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSYKMSENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETASTRFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLYEKDWASNASSGLT
  
Inhibitor
Name:
BDBM510535
Synonyms:
US11078182, Ex. 2.5
Type:
Small organic molecule
Emp. Form.:
C21H30N4O3
Mol. Mass.:
386.4879
SMILES:
CN([C@H]1CCN(C1)C(=O)c1ccc(NC2(C)CCOCC2)nc1)C(=O)C1CC1 |r|
Structure:
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