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Target
Pantetheinase [22-493]
Ligand
BDBM510544
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
1.60±n/a nM
Citation
 Fleck, MT; Godbout, C; Koolman, HF Heteroaromatic compounds as Vanin inhibitors US Patent  US11078182 Publication Date 8/3/2021 
Target
Name:
Pantetheinase [22-493]
Synonyms:
Pantetheinase (VNN1)(22-493) | VNN1 | VNN1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52490.93
Organism:
Homo sapiens (Human)
Description:
aa 22-493
Residue:
472
Sequence:
QDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDILEGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPVQERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQNLFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMNVLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLLLSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSYKMSENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETASTRFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLYEKDWASNASSGLT
  
Inhibitor
Name:
BDBM510544
Synonyms:
US11078182, Ex. 6
Type:
Small organic molecule
Emp. Form.:
C18H26N4O3
Mol. Mass.:
346.424
SMILES:
CC1CN([C@H]2CCN(C2)C(=O)c2ccc(NC(C)(C)C)nc2)C(=O)O1 |r|
Structure:
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