Reaction Details Report a problem with these data
Target
Ketohexokinase
Ligand
BDBM511678
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
280±n/a nM
Citation
 Dugar, S; Lanaspa-Garcia, M; Le, MT; Greenlee, WJ Indazole inhibitors of fructokinase (KHK) and methods of use in treating KHK-mediated disorders or diseases US Patent  US11083720 Publication Date 8/10/2021 
Target
Name:
Ketohexokinase
Synonyms:
Hepatic fructokinase | KHK | KHK_HUMAN | Ketohexokinase | Ketohexokinase (KHK) | Ketohexokinase (KHK) Isoform C
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32521.64
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
298
Sequence:
MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFMGSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDVSATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELFQLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLLHSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV
  
Inhibitor
Name:
BDBM511678
Synonyms:
4-(1-(m-tolyl)-1H-indazol-6- yl)pyridin-2-amine | US11083720, Compound C-5
Type:
Small organic molecule
Emp. Form.:
C19H16N4
Mol. Mass.:
300.3571
SMILES:
Cc1cccc(c1)-n1ncc2ccc(cc12)-c1ccnc(N)c1
Structure:
Search PDB for entries with ligand similarity: