Reaction Details Report a problem with these data
Target
Ketohexokinase
Ligand
BDBM511684
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
2300±n/a nM
Citation
 Dugar, S; Lanaspa-Garcia, M; Le, MT; Greenlee, WJ Indazole inhibitors of fructokinase (KHK) and methods of use in treating KHK-mediated disorders or diseases US Patent  US11083720 Publication Date 8/10/2021 
Target
Name:
Ketohexokinase
Synonyms:
Hepatic fructokinase | KHK | KHK_HUMAN | Ketohexokinase | Ketohexokinase (KHK) | Ketohexokinase (KHK) Isoform C
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32521.64
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
298
Sequence:
MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFMGSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDVSATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELFQLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLLHSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV
  
Inhibitor
Name:
BDBM511684
Synonyms:
N-(azetidin-3-yl)-1-(m-tolyl)- 1H-indazole-6-carboxamide | US11083720, Compound C-33
Type:
Small organic molecule
Emp. Form.:
C18H18N4O
Mol. Mass.:
306.3617
SMILES:
Cc1cccc(c1)-n1ncc2ccc(cc12)C(=O)NC1CNC1
Structure:
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