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Target
Phosphatidylinositol 4-kinase beta
Ligand
BDBM513381
Substrate
n/a
Meas. Tech.
Kinase Activity Assay
IC50
<1000±n/a nM
Citation
 Glenn, JS; Gelman, MA; Tavshanjian, B; Shokat, K; Choong, I; Smith, M PI-kinase inhibitors with anti-infective activity US Patent  US11091472 Publication Date 8/17/2021 
Target
Name:
Phosphatidylinositol 4-kinase beta
Synonyms:
NPIK | PI4-kinase beta subunit | PI4K-beta | PI4K92 | PI4KB | PI4KB_HUMAN | PI4Kbeta | PIK4B | PIK4CB | Phosphatidylinositol 4-kinase beta | Phosphatidylinositol 4-kinase, PI4K | PtdIns 4-kinase beta
Type:
Protein
Mol. Mass.:
91373.30
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
816
Sequence:
MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
  
Inhibitor
Name:
BDBM513381
Synonyms:
US11091472, Compound S-151
Type:
Small organic molecule
Emp. Form.:
C24H33N3O5S2
Mol. Mass.:
507.666
SMILES:
COc1ccc(cc1S(=O)(=O)N[C@H]1CC[C@H](O)CC1)-c1sc(NC(=O)CC2CCCC2)nc1C |r,wU:12.12,wD:15.16,(-8.77,-.91,;-7.59,-1.9,;-6.26,-1.13,;-6.26,.41,;-4.93,1.18,;-3.59,.41,;-3.59,-1.13,;-4.93,-1.9,;-4.93,-3.44,;-6.47,-3.44,;-5.33,-4.92,;-3.59,-4.21,;-2.05,-4.21,;-1.28,-2.87,;.26,-2.87,;1.03,-4.21,;2.57,-4.21,;.26,-5.54,;-1.28,-5.54,;-2.26,1.18,;-.85,.56,;.18,1.7,;1.71,1.54,;2.8,2.63,;2.4,4.12,;4.29,2.23,;5.37,3.32,;6.9,3.08,;7.59,4.45,;6.51,5.54,;5.13,4.84,;-.59,3.04,;-2.1,2.72,;-3.24,3.75,)|
Structure:
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