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Target
Phosphatidylinositol 4-kinase beta
Ligand
BDBM513386
Substrate
n/a
Meas. Tech.
Kinase Activity Assay
IC50
<1000±n/a nM
Citation
 Glenn, JS; Gelman, MA; Tavshanjian, B; Shokat, K; Choong, I; Smith, M PI-kinase inhibitors with anti-infective activity US Patent  US11091472 Publication Date 8/17/2021 
Target
Name:
Phosphatidylinositol 4-kinase beta
Synonyms:
NPIK | PI4-kinase beta subunit | PI4K-beta | PI4K92 | PI4KB | PI4KB_HUMAN | PI4Kbeta | PIK4B | PIK4CB | Phosphatidylinositol 4-kinase beta | Phosphatidylinositol 4-kinase, PI4K | PtdIns 4-kinase beta
Type:
Protein
Mol. Mass.:
91373.30
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
816
Sequence:
MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
  
Inhibitor
Name:
BDBM513386
Synonyms:
US11091472, Compound S-156
Type:
Small organic molecule
Emp. Form.:
C25H35N3O5S2
Mol. Mass.:
521.693
SMILES:
COc1ccc(cc1S(=O)(=O)NC1CC[C@H](O)CC1)-c1sc(NC(=O)CCC2CCCC2)nc1C |r,wU:15.16,(-9.65,-.5,;-8.47,-1.49,;-7.14,-.72,;-7.14,.82,;-5.81,1.59,;-4.47,.82,;-4.47,-.72,;-5.81,-1.49,;-5.81,-3.03,;-7.35,-3.03,;-6.2,-4.52,;-4.47,-3.8,;-3.14,-3.03,;-1.8,-3.8,;-.47,-3.03,;-.47,-1.49,;.86,-.72,;-1.8,-.72,;-3.14,-1.49,;-3.14,1.59,;-1.73,.96,;-.7,2.11,;.83,1.94,;1.92,3.03,;1.52,4.52,;3.41,2.63,;4.5,3.72,;5.98,3.32,;6.54,1.89,;8.07,1.97,;8.47,3.46,;7.18,4.29,;-1.47,3.44,;-2.98,3.12,;-4.12,4.15,)|
Structure:
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