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Target
Phosphatidylinositol 4-kinase beta
Ligand
BDBM513403
Substrate
n/a
Meas. Tech.
Kinase Activity Assay
IC50
<1000±n/a nM
Citation
 Glenn, JS; Gelman, MA; Tavshanjian, B; Shokat, K; Choong, I; Smith, M PI-kinase inhibitors with anti-infective activity US Patent  US11091472 Publication Date 8/17/2021 
Target
Name:
Phosphatidylinositol 4-kinase beta
Synonyms:
NPIK | PI4-kinase beta subunit | PI4K-beta | PI4K92 | PI4KB | PI4KB_HUMAN | PI4Kbeta | PIK4B | PIK4CB | Phosphatidylinositol 4-kinase beta | Phosphatidylinositol 4-kinase, PI4K | PtdIns 4-kinase beta
Type:
Protein
Mol. Mass.:
91373.30
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
816
Sequence:
MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
  
Inhibitor
Name:
BDBM513403
Synonyms:
US11091472, Compound S-193
Type:
Small organic molecule
Emp. Form.:
C25H37N3O4S2
Mol. Mass.:
507.709
SMILES:
COc1ccc(cc1S(=O)(=O)N[C@H]1CC[C@H](O)CC1)-c1sc(N[C@H](C)C2CCCCC2)nc1C |r,wU:12.12,wD:15.16,23.25,(-8.61,-.2,;-7.43,-1.18,;-6.09,-.41,;-6.09,1.13,;-4.76,1.9,;-3.43,1.13,;-3.43,-.41,;-4.76,-1.18,;-4.76,-2.72,;-6.3,-2.72,;-5.16,-4.21,;-3.43,-3.49,;-1.89,-3.49,;-1.12,-2.16,;.42,-2.16,;1.19,-3.49,;2.73,-3.49,;.42,-4.83,;-1.12,-4.83,;-2.09,1.9,;-.69,1.27,;.34,2.41,;1.88,2.25,;2.97,3.34,;2.57,4.83,;4.45,2.94,;4.85,1.46,;6.34,1.06,;7.43,2.15,;7.03,3.63,;5.54,4.03,;-.43,3.75,;-1.93,3.43,;-3.08,4.46,)|
Structure:
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