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Target
Cyclin-dependent kinase/G1/S-specific cyclin- 2
Ligand
BDBM513483
Substrate
n/a
Meas. Tech.
Kinase Inhibitory Activity Assay
IC50
73.7±n/a nM
Citation
 Yin, L; Liu, W; Li, H; Zhu, D Protein kinase inhibitors, preparation method and medical use thereof US Patent  US11091476 Publication Date 8/17/2021 
Target
Name:
Cyclin-dependent kinase/G1/S-specific cyclin- 2
Synonyms:
CDK1/D2
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Component 2
Name:
G1/S-specific cyclin-D2
Synonyms:
CCND2 | CCND2_HUMAN | CDK6/cyclin D2 | G1/S-specific cyclin-D2
Type:
PROTEIN
Mol. Mass.:
33058.33
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108400
Residue:
289
Sequence:
MELLCHEVDPVRRAVRDRNLLRDDRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQREKLSLIRKHAQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVSSLTCDALTELLAKITNTDVDCLKACQEQIEAVLLNSLQQYRQDQRDGSKSEDELDQASTPTDVRDIDL
  
Inhibitor
Name:
BDBM513483
Synonyms:
5-Fluoro-N-(5-(1-methylpiperidin-4-yl)pyridin-2-yl)-4-(2,3,3-trimethyl-3H-indol-5-yl)pyrimidine-2-amino | US11091476, Example 37
Type:
Small organic molecule
Emp. Form.:
C26H29FN6
Mol. Mass.:
444.5471
SMILES:
CN1CCC(CC1)c1ccc(Nc2ncc(F)c(n2)-c2ccc3N=C(C)C(C)(C)c3c2)nc1 |t:25|
Structure:
Search PDB for entries with ligand similarity: