Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase 30
Ligand
BDBM513597
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
<0.1±n/a nM
Citation
 Kemp, MI; Stockley, ML; Madin, A 1-cyano-pyrrolidine derivatives as inhibitors of USP30 US Patent  US11091488 Publication Date 8/17/2021 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 30
Synonyms:
Deubiquitinating enzyme 30 | UBP30_HUMAN | USP30 | Ub-specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) | Ubiquitin thioesterase 30 | Ubiquitin-specific-processing protease 30
Type:
Protein
Mol. Mass.:
58522.90
Organism:
Homo sapiens (Human)
Description:
Q70CQ3
Residue:
517
Sequence:
MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
  
Inhibitor
Name:
BDBM513597
Synonyms:
(3R,4S)-3-(5-([1,1′-biphenyl]-4-yl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl)-4-methylpyrrolidine-1-carbonitrile | US11091488, Example 39
Type:
Small organic molecule
Emp. Form.:
C20H22N4O2S
Mol. Mass.:
382.479
SMILES:
C[C@H]1CN(C[C@@H]1N1CCN(c2ccc(cc2)-c2ccccc2)S1(=O)=O)C#N |r|
Structure:
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