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Target
Ubiquitin carboxyl-terminal hydrolase 30
Ligand
BDBM513608
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
<0.1±n/a nM
Citation
 Kemp, MI; Stockley, ML; Madin, A 1-cyano-pyrrolidine derivatives as inhibitors of USP30 US Patent  US11091488 Publication Date 8/17/2021 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 30
Synonyms:
Deubiquitinating enzyme 30 | UBP30_HUMAN | USP30 | Ub-specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) | Ubiquitin thioesterase 30 | Ubiquitin-specific-processing protease 30
Type:
Protein
Mol. Mass.:
58522.90
Organism:
Homo sapiens (Human)
Description:
Q70CQ3
Residue:
517
Sequence:
MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
  
Inhibitor
Name:
BDBM513608
Synonyms:
(R)-3-(5-(2-morpholinopyridin-4-yl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl)pyrrolidine-1-carbonitrile | US11091488, Example 50
Type:
Small organic molecule
Emp. Form.:
C16H22N6O3S
Mol. Mass.:
378.449
SMILES:
O=S1(=O)N(CCN1c1ccnc(c1)N1CCOCC1)[C@@H]1CCN(C1)C#N |r|
Structure:
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