Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase 30
Ligand
BDBM513630
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
0.55±n/a nM
Citation
 Kemp, MI; Stockley, ML; Madin, A 1-cyano-pyrrolidine derivatives as inhibitors of USP30 US Patent  US11091488 Publication Date 8/17/2021 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 30
Synonyms:
Deubiquitinating enzyme 30 | UBP30_HUMAN | USP30 | Ub-specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) | Ubiquitin thioesterase 30 | Ubiquitin-specific-processing protease 30
Type:
Protein
Mol. Mass.:
58522.90
Organism:
Homo sapiens (Human)
Description:
Q70CQ3
Residue:
517
Sequence:
MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
  
Inhibitor
Name:
BDBM513630
Synonyms:
(R)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,2-dioxido-1,4-dihydro-3H-benzo[c][1,2,6]thiadiazin-3-yl)pyrrolidine-1-carbonitrile | US11091488, Example 71
Type:
Small organic molecule
Emp. Form.:
C16H18N6O2S
Mol. Mass.:
358.418
SMILES:
Cn1cc(cn1)-c1ccc2CN([C@@H]3CCN(C3)C#N)S(=O)(=O)Nc2c1 |r|
Structure:
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