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Target
Orexin receptor type 2
Ligand
BDBM118474
Substrate
n/a
Meas. Tech.
Human Orexin 2 Receptor Radioligand Binding Studies
Ki
55.0±n/a nM
Citation
 Chai, W; Letavic, MA; Ly, KS; Pippel, DJ; Rudolph, DA; Sappey, KC; Savall, BM; Shah, CR; Shireman, BT; Johnson, AS; Stocking, EM; Swanson, DM Disubstituted octahydropyrrolo[3,4-C]pyrroles as orexin receptor modulators US Patent  US11059828 Publication Date 7/13/2021 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM118474
Synonyms:
US11059828, Example 127 | US11667644, Example 127 | US8653263, 127 | US9586962, Example 127 | USRE48841, Example 127
Type:
Small organic molecule
Emp. Form.:
C26H25N7O
Mol. Mass.:
451.523
SMILES:
Cc1ccc(c(c1)C(=O)N1CC2CN(CC2C1)c1nccc(n1)-c1ccccc1)-n1nccn1
Structure:
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