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Target
Orexin receptor type 2
Ligand
BDBM118714
Substrate
n/a
Meas. Tech.
Human Orexin 2 Receptor Radioligand Binding Studies
Ki
15.0±n/a nM
Citation
 Chai, W; Letavic, MA; Ly, KS; Pippel, DJ; Rudolph, DA; Sappey, KC; Savall, BM; Shah, CR; Shireman, BT; Johnson, AS; Stocking, EM; Swanson, DM Disubstituted octahydropyrrolo[3,4-C]pyrroles as orexin receptor modulators US Patent  US11059828 Publication Date 7/13/2021 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM118714
Synonyms:
US11059828, Example 367 | US11667644, Example 367 | US8653263, 367 | US9586962, Example 472 | USRE48841, Example 367
Type:
Small organic molecule
Emp. Form.:
C24H24FN5O
Mol. Mass.:
417.4787
SMILES:
Cc1cc(C)nc(n1)N1CC2CN(CC2C1)C(=O)c1cccc(F)c1-c1ccccn1
Structure:
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