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Target
Peptidyl-prolyl cis-trans isomerase FKBP1A
Ligand
BDBM513990
Substrate
n/a
Meas. Tech.
Binding of Compounds to FKBP12
Kd
355±n/a nM
Citation
 Verdine, GL; Bowman, BR; Sowa, ME; Blodgett, JA; Robison, KE; Stiles, DT; Morgenstern, JP; Townson, SA; Shigdel, UK Compounds that participate in cooperative binding and uses thereof US Patent  US11059830 Publication Date 7/13/2021 
Target
Name:
Peptidyl-prolyl cis-trans isomerase FKBP1A
Synonyms:
12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B
Type:
Isomerase
Mol. Mass.:
11953.09
Organism:
Homo sapiens (Human)
Description:
P62942
Residue:
108
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
  
Inhibitor
Name:
BDBM513990
Synonyms:
US11059830, Compound 1
Type:
Small organic molecule
Emp. Form.:
C36H53NO6
Mol. Mass.:
595.8091
SMILES:
CCC(Cc1ccccc1)C1OC(=O)C2CCCCN2C(=O)CC2(O)OC(CCC2C)C(C)C(O)C(C)C\C=C\C\C=C\1 |t:41,44|
Structure:
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