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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM303007
Substrate
n/a
Meas. Tech.
Kinase Activity Assay
IC50
2.10±n/a nM
Citation
 Seganish, WM; McElroy, WT; Brumfield, S; Herr, RJ; Yet, L; Yang, J; Harding, III, JP; Ho, GD; Tulshian, D; Yu, W; Wong, MK; Lavey, B; Kozlowski, JA Inhibitors of IRAK4 activity US Patent  US9598440 Publication Date 3/21/2017 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM303007
Synonyms:
US9598440, 148
Type:
Small organic molecule
Emp. Form.:
C26H28N6O4S
Mol. Mass.:
520.603
SMILES:
CO[C@H]1[C@@H](C[C@@H]([C@H]1O)C(=O)OC)Nc1nc(Nc2cc(C)nc(C)c2)ncc1-c1nc2ccccc2s1 |r|
Structure:
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