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Target
Ubiquitin carboxyl-terminal hydrolase 19
Ligand
BDBM514455
Substrate
n/a
Meas. Tech.
USP19 Activity Assay
IC50
<500±n/a nM
Citation
 Hewitt, P; McFarland, MM; Rountree, JS; Burkamp, F; Bell, C; Proctor, L; Helm, MD; O''Dowd, C; Harrison, T Pharmaceutical compounds US Patent  US11053213 Publication Date 7/6/2021 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 19
Synonyms:
3.4.19.12 | Deubiquitinating enzyme 19 | KIAA0891 | UBP19_HUMAN | USP19 | Ubiquitin carboxyl-terminal hydrolase 19 | Ubiquitin thioesterase 19 | Ubiquitin-specific-processing protease 19 | ZMYND9 | Zinc finger MYND domain-containing protein 9
Type:
PROTEIN
Mol. Mass.:
145643.06
Organism:
Homo sapiens
Description:
ChEMBL_118906
Residue:
1318
Sequence:
MSGGASATGPRRGPPGLEDTTSKKKQKDRANQESKDGDPRKETGSRYVAQAGLEPLASGDPSASASHAAGITGSRHRTRLFFPSSSGSASTPQEEQTKEGACEDPHDLLATPTPELLLDWRQSAEEVIVKLRVGVGPLQLEDVDAAFTDTDCVVRFAGGQQWGGVFYAEIKSSCAKVQTRKGSLLHLTLPKKVPMLTWPSLLVEADEQLCIPPLNSQTCLLGSEENLAPLAGEKAVPPGNDPVSPAMVRSRNPGKDDCAKEEMAVAADAATLVDEPESMVNLAFVKNDSYEKGPDSVVVHVYVKEICRDTSRVLFREQDFTLIFQTRDGNFLRLHPGCGPHTTFRWQVKLRNLIEPEQCTFCFTASRIDICLRKRQSQRWGGLEAPAARVGGAKVAVPTGPTPLDSTPPGGAPHPLTGQEEARAVEKDKSKARSEDTGLDSVATRTPMEHVTPKPETHLASPKPTCMVPPMPHSPVSGDSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQQRPQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENIGYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQSPGCTTLLSTGSLEAGDSERDPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGSLPAGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNREQRLEDKGDTPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPRAGHSEHHPDLGPAAEAAASQASRIWQELEAEEEPVPEGSGPLGPWGPQDWVGPLPRGPTTPDEGCLRYFVLGTVAALVALVLNVFYPLVSQSRWR
  
Inhibitor
Name:
BDBM514455
Synonyms:
1-((7-((2,4-Dimethylpentanoyl)-10- hydroxy-7- azaspiro[4.5]decan-10-yl)methyl)-N,N- dimethyl-6-oxo-4-phenyl-1,6- dihydropyridine-3-carboxamide | US11053213, Example 197
Type:
Small organic molecule
Emp. Form.:
C31H43N3O4
Mol. Mass.:
521.6908
SMILES:
CC(C)CC(C)C(=O)N1CCC(O)(Cn2cc(C(=O)N(C)C)c(cc2=O)-c2ccccc2)C2(CCCC2)C1
Structure:
Search PDB for entries with ligand similarity: