Reaction Details Report a problem with these data
Target
Bone morphogenetic protein 10
Ligand
BDBM280349
Substrate
n/a
IC50
>1000000±n/a nM
Citation
 Rai, R; Chakravarty, S; Pujala, B; Shinde, BU; Nayak, AK; Agarwal, AK; Ramachandran, SA; Pham, SM Compounds and methods of use US Patent  US11053216 Publication Date 7/6/2021 
Target
Name:
Bone morphogenetic protein 10
Synonyms:
Alk6 | BMP10 | BMP10_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48028.70
Organism:
Homo sapiens (Human)
Description:
O95393
Residue:
424
Sequence:
MGSLVLTLCALFCLAAYLVSGSPIMNLEQSPLEEDMSLFGDVFSEQDGVDFNTLLQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLFSQPVSFNGLRKYPLLFNVSIPHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLESKGDNEGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLEIDTSAQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGCR
  
Inhibitor
Name:
BDBM280349
Synonyms:
(S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamino)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide | US10030004, Compound 16a | US10501436, Compound 16a | US11053216, Compound 16a | US11702401, Compound 16a
Type:
Small organic molecule
Emp. Form.:
C22H23ClFN5O2
Mol. Mass.:
443.902
SMILES:
C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1N(C)C)-c1cc(Cl)ccc1F |r|
Structure:
Search PDB for entries with ligand similarity: