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Target
Bone morphogenetic protein 10
Ligand
BDBM280362
Substrate
n/a
IC50
>1000000±n/a nM
Citation
 Rai, R; Chakravarty, S; Pujala, B; Shinde, BU; Nayak, AK; Agarwal, AK; Ramachandran, SA; Pham, SM Compounds and methods of use US Patent  US11053216 Publication Date 7/6/2021 
Target
Name:
Bone morphogenetic protein 10
Synonyms:
Alk6 | BMP10 | BMP10_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48028.70
Organism:
Homo sapiens (Human)
Description:
O95393
Residue:
424
Sequence:
MGSLVLTLCALFCLAAYLVSGSPIMNLEQSPLEEDMSLFGDVFSEQDGVDFNTLLQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLFSQPVSFNGLRKYPLLFNVSIPHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLESKGDNEGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLEIDTSAQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGCR
  
Inhibitor
Name:
BDBM280362
Synonyms:
N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-yl)pyridin-4-yl]amino} pyridine-3-carboxamide | US10030004, Compound 28 | US11053216, Compound 28 | US11702401, Compound 28
Type:
Small organic molecule
Emp. Form.:
C23H26N4O2
Mol. Mass.:
390.4781
SMILES:
CC(O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)C)-c1ccccc1
Structure:
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