Reaction Details Report a problem with these data
Target
Bone morphogenetic protein 10
Ligand
BDBM280368
Substrate
n/a
IC50
>10000±n/a nM
Citation
 Rai, R; Chakravarty, S; Pujala, B; Shinde, BU; Nayak, AK; Agarwal, AK; Ramachandran, SA; Pham, SM Compounds and methods of use US Patent  US11053216 Publication Date 7/6/2021 
Target
Name:
Bone morphogenetic protein 10
Synonyms:
Alk6 | BMP10 | BMP10_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48028.70
Organism:
Homo sapiens (Human)
Description:
O95393
Residue:
424
Sequence:
MGSLVLTLCALFCLAAYLVSGSPIMNLEQSPLEEDMSLFGDVFSEQDGVDFNTLLQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLFSQPVSFNGLRKYPLLFNVSIPHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLESKGDNEGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLEIDTSAQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGCR
  
Inhibitor
Name:
BDBM280368
Synonyms:
2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[3-(pyrrolidine-1-carbonyl)pyridin-4-yl]pyridin-4-amine | US10030004, Compound 34 | US10501436, Compound 34 | US11053216, Compound 34 | US11702401, Compound 34
Type:
Small organic molecule
Emp. Form.:
C24H22ClFN4O
Mol. Mass.:
436.909
SMILES:
CC(=C)c1cnc(cc1Nc1ccncc1C(=O)N1CCCC1)-c1cc(Cl)ccc1F
Structure:
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