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Target
Tryptophan 2,3-dioxygenase
Ligand
BDBM514513
Substrate
n/a
Meas. Tech.
Biochemical Coupled Assay
IC50
513±n/a nM
Citation
 Cowley, PM; McGowan, MA; Brown, TJ; Han, Y; Liu, K; Pu, Q; Wise, A; Zhang, H; Zhou, H Substituted imidazopyridine compounds as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan-2,3-dioxygenase US Patent  US11096930 Publication Date 8/24/2021 
Target
Name:
Tryptophan 2,3-dioxygenase
Synonyms:
T23O_HUMAN | TDO | TDO2 | TO | TRPO | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase
Type:
PROTEIN
Mol. Mass.:
47874.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_825691
Residue:
406
Sequence:
MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
  
Inhibitor
Name:
BDBM514513
Synonyms:
8-(7-bromoimidazo[1,5- a]pyridin-5-yl)-1,3,8- triazaspiro[4.5]decane-2,4- dione | US11096930, Example 2
Type:
Small organic molecule
Emp. Form.:
C14H14BrN5O2
Mol. Mass.:
364.197
SMILES:
Brc1cc(N2CCC3(CC2)NC(=O)NC3=O)n2cncc2c1
Structure:
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