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Target
Tryptophan 2,3-dioxygenase
Ligand
BDBM514527
Substrate
n/a
Meas. Tech.
Biochemical Coupled Assay
IC50
1585±n/a nM
Citation
 Cowley, PM; McGowan, MA; Brown, TJ; Han, Y; Liu, K; Pu, Q; Wise, A; Zhang, H; Zhou, H Substituted imidazopyridine compounds as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan-2,3-dioxygenase US Patent  US11096930 Publication Date 8/24/2021 
Target
Name:
Tryptophan 2,3-dioxygenase
Synonyms:
T23O_HUMAN | TDO | TDO2 | TO | TRPO | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase
Type:
PROTEIN
Mol. Mass.:
47874.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_825691
Residue:
406
Sequence:
MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
  
Inhibitor
Name:
BDBM514527
Synonyms:
8-(7-chloroimidazo[1,5- a]pyridin-5-yl)-6,6-dimethyl- 1,3,8-triazaspiro[4.5]decane- 2,4-dione | US11096930, Example 11 | US11096930, Example 8
Type:
Small organic molecule
Emp. Form.:
C16H18ClN5O2
Mol. Mass.:
347.799
SMILES:
CC1(C)CN(CCC11NC(=O)NC1=O)c1cc(Cl)cc2cncn12
Structure:
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