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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM514528
Substrate
n/a
Meas. Tech.
Biochemical Coupled Assay
IC50
263±n/a nM
Citation
 Cowley, PM; McGowan, MA; Brown, TJ; Han, Y; Liu, K; Pu, Q; Wise, A; Zhang, H; Zhou, H Substituted imidazopyridine compounds as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan-2,3-dioxygenase US Patent  US11096930 Publication Date 8/24/2021 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM514528
Synonyms:
3-phenyl-8-(7- (trifluoromethyl)imidazo[1,5- a]pyridin-5-yl)-1,3,8- triazaspiro[4.5]decane-2,4- dione | US11096930, Example 9
Type:
Small organic molecule
Emp. Form.:
C21H18F3N5O2
Mol. Mass.:
429.3951
SMILES:
FC(F)(F)c1cc(N2CCC3(CC2)NC(=O)N(C3=O)c2ccccc2)n2cncc2c1
Structure:
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