Reaction Details Report a problem with these data
Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM514559
Substrate
n/a
Meas. Tech.
Biochemical Coupled Assay
IC50
87.1±n/a nM
Citation
 Cowley, PM; McGowan, MA; Brown, TJ; Han, Y; Liu, K; Pu, Q; Wise, A; Zhang, H; Zhou, H Substituted imidazopyridine compounds as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan-2,3-dioxygenase US Patent  US11096930 Publication Date 8/24/2021 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM514559
Synonyms:
8-(7-bromoimidazo[1,5- a]pyridin-5-yl)-6,6-dimethyl- 1,3,8-triazaspiro[4.5]decane- 2,4-dione | US11096930, Example 16
Type:
Small organic molecule
Emp. Form.:
C16H18BrN5O2
Mol. Mass.:
392.25
SMILES:
CC1(C)CN(CCC11NC(=O)NC1=O)c1cc(Br)cc2cncn12
Structure:
Search PDB for entries with ligand similarity: