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Target
Tyrosine-protein kinase BTK
Ligand
BDBM514818
Substrate
n/a
Meas. Tech.
Microfluidic Off-Chip Mobility Shift Assay Protocol for Potency Assessment Against BTK Enzyme
IC50
<100±n/a nM
Citation
 Gaillard, P; Seenisamy, J; Liu-Bujalski, L; Caldwell, RD; Potnick, J; Qiu, H; Neagu, C; Jones, R; Won, AC; Goutopoulos, A; Sherer, BA; Johnson, TL; Gardberg, A Heteroaryl compounds as BTK inhibitors and uses thereof US Patent  US11098041 Publication Date 8/24/2021 
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM514818
Synonyms:
US11098041, Example 42
Type:
Small organic molecule
Emp. Form.:
C29H25FN6O3
Mol. Mass.:
524.5456
SMILES:
Cn1cc(cn1)-c1nc2nccc(-c3cccc(N4CCOc5cc(cc(F)c5C4=O)C4CC4)c3CO)c2[nH]1
Structure:
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