Reaction Details Report a problem with these data
Target
Potassium channel subfamily K member 9
Ligand
BDBM515566
Substrate
n/a
Meas. Tech.
Inhibition of Recombinant TASK-1 and TASK-3 In Vitro
IC50
8.40±n/a nM
Citation
 Delbeck, M; Hahn, M; Müller, T; Lustig, K; Collins, K; Lindner, N; Nicolai, J; Beck-Broichsitter, M; Albus, U; Gehring, D; Rosenstein, B Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders US Patent  US11098063 Publication Date 8/24/2021 
Target
Name:
Potassium channel subfamily K member 9
Synonyms:
Acid-sensitive potassium channel protein TASK-3 | KCNK9 | KCNK9_HUMAN | TASK3 | TWIK-related acid-sensitive K(+) channel 3 | Two pore K(+) channel KT3.2 | Two pore potassium channel KT3.2
Type:
PROTEIN
Mol. Mass.:
42276.04
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1457494
Residue:
374
Sequence:
MKRQNVRTLSLIVCTFTYLLVGAAVFDALESDHEMREEEKLKAEEIRIKGKYNISSEDYRQLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTDVSMENMVTVGFFSCMGTLCIGAAAFSQCEEWSFFHAYYYCFITLTTIGFGDYVALQTKGALQKKPLYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNSEDERRDAEERASLAGNRNSMVIHIPEEPRPSRPRYKADVPDLQSVCSCTCYRSQDYGGRSVAPQNSFSAKLAPHYFHSISYKIEEISPSTLKNSLFPSPISSISPGLHSFTDHQRLMKRRKSV
  
Inhibitor
Name:
BDBM515566
Synonyms:
US11098063, Example 64
Type:
Small organic molecule
Emp. Form.:
C29H30FN5O
Mol. Mass.:
483.5798
SMILES:
CC(C)c1ccc(cc1)-c1nc2ncccn2c1CN1CC2CCC(C1)N2C(=O)c1ccccc1F
Structure:
Search PDB for entries with ligand similarity: