Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase Mer
Ligand
BDBM515806
Substrate
n/a
Meas. Tech.
Verification on Inhibitory Activities of TAM Receptor Inhibiting Compounds on Tyro 3, Axl, and Mer
IC50
0.900±n/a nM
Citation
 Cho, SY; Lee, CH; Min, YK; Hwang, JY Pyrimidine derivative compound, optical isomer thereof, or pharmaceutically acceptable salt thereof, and composition for preventing or treating Tyro 3 related disease comprising same as active ingredient US Patent  US11053225 Publication Date 7/6/2021 
Target
Name:
Tyrosine-protein kinase Mer
Synonyms:
MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer
Type:
PROTEIN
Mol. Mass.:
110234.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1498723
Residue:
999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
  
Inhibitor
Name:
BDBM515806
Synonyms:
US11053225, Compound 115
Type:
Small organic molecule
Emp. Form.:
C23H24F5N7O2
Mol. Mass.:
525.4744
SMILES:
OCCn1cc(cn1)-c1cnc(Nc2cc(F)cc(F)c2)nc1NC1CC[C@@H](CC1)NC(=O)C(F)(F)F |r,wD:27.33,(3.3,-10.38,;4.21,-9.13,;3.58,-7.72,;4.49,-6.48,;4.01,-5.01,;5.26,-4.11,;6.5,-5.01,;6.03,-6.48,;5.26,-2.57,;6.59,-1.8,;6.59,-.26,;5.26,.51,;5.26,2.05,;3.92,2.82,;2.59,2.05,;1.26,2.82,;-.08,2.05,;1.26,4.36,;2.59,5.13,;2.59,6.67,;3.92,4.36,;3.92,-.26,;3.92,-1.8,;2.59,-2.57,;1.26,-1.8,;-.08,-2.57,;-1.41,-1.8,;-1.41,-.26,;-.08,.51,;1.26,-.26,;-2.74,.51,;-2.74,2.05,;-1.41,2.82,;-4.08,2.82,;-5.41,3.59,;-3.31,4.16,;-4.85,1.49,)|
Structure:
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