Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase Mer
Ligand
BDBM515807
Substrate
n/a
Meas. Tech.
Verification on Inhibitory Activities of TAM Receptor Inhibiting Compounds on Tyro 3, Axl, and Mer
IC50
1.000±n/a nM
Citation
 Cho, SY; Lee, CH; Min, YK; Hwang, JY Pyrimidine derivative compound, optical isomer thereof, or pharmaceutically acceptable salt thereof, and composition for preventing or treating Tyro 3 related disease comprising same as active ingredient US Patent  US11053225 Publication Date 7/6/2021 
Target
Name:
Tyrosine-protein kinase Mer
Synonyms:
MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer
Type:
PROTEIN
Mol. Mass.:
110234.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1498723
Residue:
999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
  
Inhibitor
Name:
BDBM515807
Synonyms:
US11053225, Compound 117
Type:
Small organic molecule
Emp. Form.:
C21H25F2N7O
Mol. Mass.:
429.4663
SMILES:
N[C@H]1CCC(CC1)Nc1nc(Nc2cc(F)cc(F)c2)ncc1-c1cnn(CCO)c1 |r,wU:1.0,(5.88,3.85,;4.55,3.08,;4.55,1.54,;3.22,.77,;1.88,1.54,;1.88,3.08,;3.22,3.85,;.55,.77,;.55,-.77,;1.88,-1.54,;1.88,-3.08,;3.22,-3.85,;4.55,-3.08,;5.88,-3.85,;7.22,-3.08,;8.55,-3.85,;7.22,-1.54,;5.88,-.77,;5.88,.77,;4.55,-1.54,;.55,-3.85,;-.78,-3.08,;-.78,-1.54,;-2.12,-.77,;-2.12,.77,;-3.58,1.25,;-4.49,,;-5.98,-.4,;-7.06,.69,;-8.55,.29,;-3.58,-1.25,)|
Structure:
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