Reaction Details Report a problem with these data
Target
GTPase KRas [1-169,G12C,C118A]
Ligand
BDBM515938
Substrate
n/a
Meas. Tech.
Coupled Nucleotide Exchange Assay (20 hours)
IC50
180.00±n/a nM
Citation
Shin, Y; Cee, VJ; Tegley, CM; Lanman, BA; Wurz, RP; Yang, KC; Ma, VV; Erlanson, D; Jeong, JW; Fucini, RV; Iwig, J KRAS G12C inhibitors and methods of using the same US Patent US11053226 Publication Date 7/6/2021
More Info.:
Target
Name:
GTPase KRas [1-169,G12C,C118A]
Synonyms:
GTPase KRas | KRAS | KRAS2 | RASK2 | RASK_HUMAN
Type:
PROTEIN
Mol. Mass.:
19407.24
Organism:
Homo sapiens (Human)
Description:
P01116[1-169,G12C,C118A]
Residue:
169
Sequence:
MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKADLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK