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Target
Histone-lysine N-methyltransferase EZH2 [Y641F]
Ligand
BDBM516843
Substrate
n/a
Meas. Tech.
In Vitro Methyltransferase Activity Assay
IC50
7.00±n/a nM
Citation
 Peng, J; Liu, Y; Wang, L; Fang, Z; Fei, Z; Chen, X; Lan, J 4,5,6-trisubstituted indazole derivatives, and preparation method and pharmaceutical use thereof US Patent  US11104664 Publication Date 8/31/2021 
Target
Name:
Histone-lysine N-methyltransferase EZH2 [Y641F]
Synonyms:
EZH2 | EZH2(Y641F) | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (Y641F) | KMT6
Type:
n/a
Mol. Mass.:
85351.84
Organism:
Homo sapiens (Human)
Description:
Q15910[Y641F]
Residue:
746
Sequence:
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEFCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
  
Inhibitor
Name:
BDBM516843
Synonyms:
US11104664, Compound P-15
Type:
Small organic molecule
Emp. Form.:
C30H44N6O4
Mol. Mass.:
552.7082
SMILES:
CCN(C1CCC(CC1)N(C)CCOC)c1c(C)c(cc2n(C)ncc12)C(=O)NCc1c(OC)cc(C)[nH]c1=O |(2.67,-4.62,;2.67,-3.08,;1.33,-2.31,;,-3.08,;,-4.62,;-1.33,-5.39,;-2.67,-4.62,;-2.67,-3.08,;-1.33,-2.31,;-4,-5.39,;-4,-6.93,;-5.33,-4.62,;-6.67,-5.39,;-8,-4.62,;-9.34,-5.39,;1.33,-.77,;2.67,,;4,-.77,;2.67,1.54,;1.33,2.31,;,1.54,;-1.46,2.02,;-1.94,3.48,;-2.37,.77,;-1.46,-.48,;;4,2.31,;5.33,1.54,;4,3.85,;5.33,4.62,;5.33,6.16,;6.67,6.93,;8,6.16,;8,4.62,;6.67,8.47,;5.33,9.24,;5.33,10.78,;4,8.47,;4,6.93,;2.67,6.16,)|
Structure:
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