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Target
Histone-lysine N-methyltransferase EZH2 [Y641F]
Ligand
BDBM516855
Substrate
n/a
Meas. Tech.
In Vitro Methyltransferase Activity Assay
IC50
8.00±n/a nM
Citation
 Peng, J; Liu, Y; Wang, L; Fang, Z; Fei, Z; Chen, X; Lan, J 4,5,6-trisubstituted indazole derivatives, and preparation method and pharmaceutical use thereof US Patent  US11104664 Publication Date 8/31/2021 
Target
Name:
Histone-lysine N-methyltransferase EZH2 [Y641F]
Synonyms:
EZH2 | EZH2(Y641F) | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (Y641F) | KMT6
Type:
n/a
Mol. Mass.:
85351.84
Organism:
Homo sapiens (Human)
Description:
Q15910[Y641F]
Residue:
746
Sequence:
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEFCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
  
Inhibitor
Name:
BDBM516855
Synonyms:
US11104664, Compound P-26
Type:
Small organic molecule
Emp. Form.:
C29H42N6O2
Mol. Mass.:
506.6828
SMILES:
CCN(C1CCC(CN(C)C)CC1)c1c(C)c(cc2n(C)ncc12)C(=O)NCc1c(C)cc(C)[nH]c1=O |(3.33,.38,;1.99,1.15,;.66,.38,;.66,-1.16,;-.68,-1.93,;-.68,-3.47,;.66,-4.24,;.66,-5.78,;1.99,-6.55,;1.99,-8.09,;3.33,-5.78,;1.99,-3.47,;1.99,-1.93,;-.68,1.15,;-.68,2.69,;.66,3.46,;-2.01,3.47,;-3.34,2.69,;-3.34,1.15,;-4.49,.12,;-5.99,.44,;-3.86,-1.28,;-2.33,-1.12,;-2.01,.39,;-2.01,5.01,;-3.34,5.78,;-.68,5.78,;.66,5.01,;1.99,5.78,;3.33,5.01,;3.33,3.47,;4.66,5.78,;4.66,7.32,;5.99,8.09,;3.33,8.09,;1.99,7.32,;.66,8.09,)|
Structure:
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