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Target
Histone-lysine N-methyltransferase EZH2 [Y641F]
Ligand
BDBM516860
Substrate
n/a
Meas. Tech.
In Vitro Methyltransferase Activity Assay
IC50
15.0±n/a nM
Citation
 Peng, J; Liu, Y; Wang, L; Fang, Z; Fei, Z; Chen, X; Lan, J 4,5,6-trisubstituted indazole derivatives, and preparation method and pharmaceutical use thereof US Patent  US11104664 Publication Date 8/31/2021 
Target
Name:
Histone-lysine N-methyltransferase EZH2 [Y641F]
Synonyms:
EZH2 | EZH2(Y641F) | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (Y641F) | KMT6
Type:
n/a
Mol. Mass.:
85351.84
Organism:
Homo sapiens (Human)
Description:
Q15910[Y641F]
Residue:
746
Sequence:
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEFCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
  
Inhibitor
Name:
BDBM516860
Synonyms:
US11104664, Compound P-31
Type:
Small organic molecule
Emp. Form.:
C29H38F2N6O2
Mol. Mass.:
540.6478
SMILES:
CCN(C1CCC(CC1)N1CC(F)(F)C1)c1c(C)c(cc2n(C)ncc12)C(=O)NCc1c(C)cc(C)[nH]c1=O |(3.33,.99,;1.99,1.76,;.66,.99,;.66,-.55,;-.68,-1.32,;-.68,-2.86,;.66,-3.63,;1.99,-2.86,;1.99,-1.32,;.66,-5.17,;-.43,-6.26,;.66,-7.35,;-.11,-8.69,;1.43,-8.69,;1.75,-6.26,;-.68,1.76,;-.68,3.3,;.66,4.07,;-2.01,4.07,;-3.34,3.3,;-3.34,1.76,;-4.49,.73,;-5.99,1.05,;-3.86,-.68,;-2.33,-.52,;-2.01,.99,;-2.01,5.61,;-3.34,6.38,;-.68,6.38,;.66,5.61,;1.99,6.38,;3.33,5.61,;3.33,4.07,;4.66,6.38,;4.66,7.92,;5.99,8.69,;3.33,8.69,;1.99,7.92,;.66,8.69,)|
Structure:
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