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Target
Histone-lysine N-methyltransferase EZH2 [Y641F]
Ligand
BDBM516866
Substrate
n/a
Meas. Tech.
In Vitro Methyltransferase Activity Assay
IC50
7.00±n/a nM
Citation
 Peng, J; Liu, Y; Wang, L; Fang, Z; Fei, Z; Chen, X; Lan, J 4,5,6-trisubstituted indazole derivatives, and preparation method and pharmaceutical use thereof US Patent  US11104664 Publication Date 8/31/2021 
Target
Name:
Histone-lysine N-methyltransferase EZH2 [Y641F]
Synonyms:
EZH2 | EZH2(Y641F) | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (Y641F) | KMT6
Type:
n/a
Mol. Mass.:
85351.84
Organism:
Homo sapiens (Human)
Description:
Q15910[Y641F]
Residue:
746
Sequence:
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEFCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
  
Inhibitor
Name:
BDBM516866
Synonyms:
US11104664, Compound P-39
Type:
Small organic molecule
Emp. Form.:
C32H46N6O3
Mol. Mass.:
562.746
SMILES:
CCOC1CN(C1)C1CCC(CC1)N(CC)c1c(CC)c(cc2n(C)ncc12)C(=O)NCc1c(C)cc(C)[nH]c1=O |(3.33,-8.4,;1.99,-9.17,;.66,-8.4,;.66,-6.86,;-.43,-5.78,;.66,-4.69,;1.75,-5.78,;.66,-3.15,;-.68,-2.38,;-.68,-.84,;.66,-.07,;1.99,-.84,;1.99,-2.38,;.66,1.47,;1.99,2.24,;3.33,1.47,;-.68,2.24,;-.68,3.78,;.66,4.55,;1.99,3.78,;-2.01,4.55,;-3.34,3.78,;-3.34,2.24,;-4.49,1.21,;-5.99,1.53,;-3.86,-.19,;-2.33,-.03,;-2.01,1.47,;-2.01,6.09,;-3.34,6.86,;-.68,6.86,;.66,6.09,;1.99,6.86,;3.33,6.09,;3.33,4.55,;4.66,6.86,;4.66,8.4,;5.99,9.17,;3.33,9.17,;1.99,8.4,;.66,9.17,)|
Structure:
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