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Target
Activin receptor type-1 [147-509]
Ligand
BDBM518168
Substrate
n/a
Meas. Tech.
HTRF Assay (3 uM ATP)
IC50
<100±n/a nM
Citation
 Vechorkin, O; Nguyen, M; Qi, C; Wang, A; Wu, L; Yao, W; Zhao, P Pyrazolopyrimidine compounds and uses thereof US Patent  US11111247 Publication Date 9/7/2021 
Target
Name:
Activin receptor type-1 [147-509]
Synonyms:
ACVR1 | ACVR1_HUMAN | ACVRLK2 | Activin receptor-like kinase 2 (ALK-2) (aa 147-509)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41331.39
Organism:
Homo sapiens (Human)
Description:
aa147-end
Residue:
363
Sequence:
RKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
  
Inhibitor
Name:
BDBM518168
Synonyms:
US11111247, Example 4
Type:
Small organic molecule
Emp. Form.:
C22H28N8O
Mol. Mass.:
420.5107
SMILES:
C[C@@H]1CN(CCN1)c1ccc(cn1)-c1n[nH]c2cnc(nc12)N1[C@H]2C[C@H](O)[C@@H]1CCC2 |r,THB:19:22:28.29.30:24.25|
Structure:
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