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Target
Activin receptor type-1 [147-509]
Ligand
BDBM518172
Substrate
n/a
Meas. Tech.
HTRF Assay (100 uM ATP)
IC50
<100±n/a nM
Citation
 Vechorkin, O; Nguyen, M; Qi, C; Wang, A; Wu, L; Yao, W; Zhao, P Pyrazolopyrimidine compounds and uses thereof US Patent  US11111247 Publication Date 9/7/2021 
Target
Name:
Activin receptor type-1 [147-509]
Synonyms:
ACVR1 | ACVR1_HUMAN | ACVRLK2 | Activin receptor-like kinase 2 (ALK-2) (aa 147-509)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41331.39
Organism:
Homo sapiens (Human)
Description:
aa147-end
Residue:
363
Sequence:
RKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
  
Inhibitor
Name:
BDBM518172
Synonyms:
US11111247, Example 8
Type:
Small organic molecule
Emp. Form.:
C24H34N10O
Mol. Mass.:
478.5932
SMILES:
C[C@@H]1CN(CCN1)c1ccc(cn1)-c1n[nH]c2cnc(nc12)N1[C@@H](C)CN(C[C@H]1C)C(=O)N(C)C |r|
Structure:
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