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Target
Cyclin-dependent kinase 2
Ligand
BDBM50539906
Substrate
n/a
Meas. Tech.
Pulldown Assay
IC50
15.7±n/a nM
Citation
 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Inhibitors of cyclin-dependent kinases US Patent  US11142507 Publication Date 10/12/2021 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50539906
Synonyms:
CHEMBL4648005 | US11142507, Compound MFH-3-35-1
Type:
Small organic molecule
Emp. Form.:
C26H33N5O2S2
Mol. Mass.:
511.703
SMILES:
CC(C)(C)c1cnc(CSc2cnc(NC3CCCC(C3)Nc3ccc(NC(=O)C=C)cc3)s2)o1
Structure:
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