Reaction Details Report a problem with these data
Target
L-lactate dehydrogenase A chain
Ligand
BDBM519549
Substrate
n/a
Meas. Tech.
Coupled Diaphorase Assay
IC50
30000±n/a nM
Citation
 Klaveness, J; Sieng, B; Lundvall, S; Bøen, CA; Hnida, K LDHA activity inhibitors US Patent  US11142520 Publication Date 10/12/2021 
Target
Name:
L-lactate dehydrogenase A chain
Synonyms:
Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59
Type:
Protein
Mol. Mass.:
36694.85
Organism:
Homo sapiens (Human)
Description:
P00338::PDB Code: 4ajp
Residue:
332
Sequence:
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF
  
Inhibitor
Name:
BDBM519549
Synonyms:
US11142520, Example 7
Type:
Small organic molecule
Emp. Form.:
C26H24Cl2N2O3S2
Mol. Mass.:
547.516
SMILES:
Clc1cccc(SC2C(=O)CC(NC2=O)(c2ccsc2)c2cccc(OCC3CCCC3)n2)c1Cl
Structure:
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