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Target
Gamma-aminobutyric acid receptor subunit alpha-1
Ligand
BDBM520667
Substrate
n/a
Meas. Tech.
Steroid Inhibition of TBPS Binding
IC50
>500±n/a nM
Citation
 Robichaud, AJ; Martinez Botella, G; Salituro, FG; Harrison, BL Compositions and methods for treating CNS disorders US Patent  US11147877 Publication Date 10/19/2021 
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-1
Synonyms:
Benzodiazepine central | Benzodiazepine receptors | GABA A Benzodiazepine | GABA A Benzodiazepine Type I | GABA A Benzodiazepine Type II | GABA A Benzodiazepine Type IIL | GABA A Benzodiazepine Type IIM | GABA A Benzodiazepine omega1 | GABA A Benzodiazepine omega2 | GABA A Benzodiazepine omega5 | GABA A alpha1 | GABA A anti-Alpha1 | GABA receptor alpha-1 subunit | GABA, Chloride, TBOB | GABA-PICROTOXIN | GBRA1_RAT | Gabra-1 | Gabra1 | TBPS
Type:
Enzyme
Mol. Mass.:
51770.21
Organism:
Rattus norvegicus (Rat)
Description:
P62813
Residue:
455
Sequence:
MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
  
Inhibitor
Name:
BDBM520667
Synonyms:
US11147877, Compound 16
Type:
Small organic molecule
Emp. Form.:
C26H36N2O
Mol. Mass.:
392.5768
SMILES:
C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2c1cn2ccccc2n1 |r|
Structure:
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