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Target
Substance-P receptor
Ligand
BDBM520672
Substrate
n/a
Meas. Tech.
Tag-Lite Tachykinin NK-1 receptor binding assay
IC50
0.640±n/a nM
Citation
 Xiang, J; Xu, X; Feng, Y; Liu, X; Eng, W Compounds as neurokinin-1 receptor antagonists and uses thereof US Patent  US11149006 Publication Date 10/19/2021 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM520672
Synonyms:
US11149006, Compound I | US11149006, Compound IV
Type:
Small organic molecule
Emp. Form.:
C19H23F5N2OS
Mol. Mass.:
422.456
SMILES:
COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)S(F)(F)(F)(F)F |r|
Structure:
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