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Target
Prostaglandin F2-alpha receptor
Ligand
BDBM520874
Substrate
n/a
Meas. Tech.
In Vitro Test of Inhibition of Human FP Receptor Activity
IC50
1.60±n/a nM
Citation
 Beck, H; Kast, R; Meininghaus, M; Fuerstner, C; Stellfeld, T; Von Buehler, C; Dietz, L; Bairlein, M; Anlahr, J; Joerissen, H; Hauff, P; Mueller, J; Droebner, K; Nagel, J Substituted N-arylethyl-2-aminoquinoline-4-carboxamides and use thereof US Patent  US11149018 Publication Date 10/19/2021 
Target
Name:
Prostaglandin F2-alpha receptor
Synonyms:
PF2R_HUMAN | PGF receptor | PGF2 alpha receptor | PGF2-alpha receptor | PTGFR | Prostaglandin F | Prostanoid FP receptor
Type:
Enzyme
Mol. Mass.:
40072.29
Organism:
Homo sapiens (Human)
Description:
P43088
Residue:
359
Sequence:
MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
  
Inhibitor
Name:
BDBM520874
Synonyms:
5-[({6-Bromo-2-[3-ethylpiperidin-1-yl]-3-methylquinolin-4-yl}carbonyl)amino]-4-(2-chloro-3,6-difluorophenyl)pentanoic acid (Diastereomer Mixture) | US11149018, Example 158
Type:
Small organic molecule
Emp. Form.:
C29H31BrClF2N3O3
Mol. Mass.:
622.929
SMILES:
CCC1CCCN(C1)c1nc2ccc(Br)cc2c(C(=O)NCC(CCC(O)=O)c2c(F)ccc(F)c2Cl)c1C
Structure:
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