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Target
Prostaglandin F2-alpha receptor
Ligand
BDBM521009
Substrate
n/a
Meas. Tech.
In Vitro Test of Inhibition of Human FP Receptor Activity
IC50
2.40±n/a nM
Citation
 Beck, H; Kast, R; Meininghaus, M; Fuerstner, C; Stellfeld, T; Von Buehler, C; Dietz, L; Bairlein, M; Anlahr, J; Joerissen, H; Hauff, P; Mueller, J; Droebner, K; Nagel, J Substituted N-arylethyl-2-aminoquinoline-4-carboxamides and use thereof US Patent  US11149018 Publication Date 10/19/2021 
Target
Name:
Prostaglandin F2-alpha receptor
Synonyms:
PF2R_HUMAN | PGF receptor | PGF2 alpha receptor | PGF2-alpha receptor | PTGFR | Prostaglandin F | Prostanoid FP receptor
Type:
Enzyme
Mol. Mass.:
40072.29
Organism:
Homo sapiens (Human)
Description:
P43088
Residue:
359
Sequence:
MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
  
Inhibitor
Name:
BDBM521009
Synonyms:
(+)-5-({[6-Bromo-2-(3,3-difluoropiperidin-1-yl)-3-methylquinolin-4-yl]carbonyl}amino)-4-(2-methoxyphenyl)pentanoic acid (Enantiomer 1) | US11149018, Example 289
Type:
Small organic molecule
Emp. Form.:
C28H30BrF2N3O4
Mol. Mass.:
590.456
SMILES:
COc1ccccc1[C@@H](CCC(O)=O)CNC(=O)c1c(C)c(nc2ccc(Br)cc12)N1CCCC(F)(F)C1 |r|
Structure:
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