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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM521058
Substrate
n/a
Meas. Tech.
Cell-Based Functional Assay of Muscarinic Acetylcholine Receptor Activity
IC50
760±n/a nM
Citation
 Lindsley, CW; Conn, PJ; Engers, DW; Bender, AM; Engers, JL Antagonists of the muscarinic acetylcholine receptor M4 US Patent  US11149022 Publication Date 10/19/2021 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53079.31
Organism:
Homo sapiens (Human)
Description:
Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173
Residue:
479
Sequence:
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM521058
Synonyms:
2-[6-(2-chloro-5-fluoro-phenyl)pyridazin-3- yl]oxy-7-(cyclohexylmethyl)-7- azaspiro[3.5]nonane | US11149022, Cpd. No. 18
Type:
Small organic molecule
Emp. Form.:
C25H31ClFN3O
Mol. Mass.:
443.985
SMILES:
Fc1ccc(Cl)c(c1)-c1ccc(OC2CC3(C2)CCN(CC2CCCCC2)CC3)nn1
Structure:
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