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Target
Serine protease HTRA2, mitochondrial
Ligand
BDBM521745
Substrate
n/a
Meas. Tech.
Chromogenic Enzyme Activity Assays
Ki
490±110 nM
Citation
 Kaiser, M; Köcher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors US Patent  US11149067 Publication Date 10/19/2021 
Target
Name:
Serine protease HTRA2, mitochondrial
Synonyms:
HTRA2 | HTRA2_HUMAN | High temperature requirement protein A2 | OMI | Omi stress-regulated endoprotease | PRSS25 | Serine protease 25 | Serine protease HTRA2 (aa 138-458), mitochondrial | Serine proteinase OMI
Type:
Protein
Mol. Mass.:
48853.34
Organism:
Human
Description:
O43464[138-458]
Residue:
458
Sequence:
MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
  
Inhibitor
Name:
BDBM521745
Synonyms:
US11149067, Compound Ahp4
Type:
Small organic molecule
Emp. Form.:
C55H74N8O12
Mol. Mass.:
1039.2225
SMILES:
CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C(C)C)C2=O |r|
Structure:
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