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Target
Serine protease HTRA1 [158-480]
Ligand
BDBM521752
Substrate
n/a
Meas. Tech.
Chromogenic Enzyme Activity Assays
Ki
>50000±n/a nM
Citation
 Kaiser, M; Köcher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors US Patent  US11149067 Publication Date 10/19/2021 
Target
Name:
Serine protease HTRA1 [158-480]
Synonyms:
HTRA | HTRA1 | HTRA1_HUMAN | PRSS11 | Serine protease HTRA1 (aa 158-480)
Type:
Protein
Mol. Mass.:
35192.41
Organism:
Homo sapiens (Human)
Description:
Q92743[158-480]
Residue:
323
Sequence:
GQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
  
Inhibitor
Name:
BDBM521752
Synonyms:
US11149067, Compound Ahp11
Type:
Small organic molecule
Emp. Form.:
C49H71N7O10
Mol. Mass.:
918.1289
SMILES:
CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)CCc3ccccc3)[C@H](OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C(C)C)C(C)C)C2=O |r|
Structure:
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