Reaction Details Report a problem with these data
Target
Prostaglandin F2-alpha receptor
Ligand
BDBM523453
Substrate
n/a
Meas. Tech.
In Vitro Test of Inhibition of Human FP Receptor Activity
IC50
7.70±n/a nM
Citation
 Beck, H; Kast, R; Meininghaus, M; Dietz, L; Fuerstner, C; Stellfeld, T; Anlauf, S; Von Buehler, C; Bairlein, M; Anlahr, J; Muenster, U; Terjung, C; Joerissen, H; Hauff, P; Mueller, J; Droebner, K; Nagel, J Substituted N-arylethyl-2-arylquinoline-4-carboxamides and use thereof US Patent  US11136296 Publication Date 10/5/2021 
Target
Name:
Prostaglandin F2-alpha receptor
Synonyms:
PF2R_HUMAN | PGF receptor | PGF2 alpha receptor | PGF2-alpha receptor | PTGFR | Prostaglandin F | Prostanoid FP receptor
Type:
Enzyme
Mol. Mass.:
40072.29
Organism:
Homo sapiens (Human)
Description:
P43088
Residue:
359
Sequence:
MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
  
Inhibitor
Name:
BDBM523453
Synonyms:
(+/-)-5-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}-4-(2-chloro-3-fluorophenyl)pentanoic Acid (Racemate) | US11136296, Example 184
Type:
Small organic molecule
Emp. Form.:
C28H23BrClFN2O3
Mol. Mass.:
569.849
SMILES:
Cc1c(nc2ccc(Br)cc2c1C(=O)NCC(CCC(O)=O)c1cccc(F)c1Cl)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: