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Target
Prostaglandin F2-alpha receptor
Ligand
BDBM523484
Substrate
n/a
Meas. Tech.
In Vitro Test of Inhibition of Human FP Receptor Activity
IC50
5.40±n/a nM
Citation
 Beck, H; Kast, R; Meininghaus, M; Dietz, L; Fuerstner, C; Stellfeld, T; Anlauf, S; Von Buehler, C; Bairlein, M; Anlahr, J; Muenster, U; Terjung, C; Joerissen, H; Hauff, P; Mueller, J; Droebner, K; Nagel, J Substituted N-arylethyl-2-arylquinoline-4-carboxamides and use thereof US Patent  US11136296 Publication Date 10/5/2021 
Target
Name:
Prostaglandin F2-alpha receptor
Synonyms:
PF2R_HUMAN | PGF receptor | PGF2 alpha receptor | PGF2-alpha receptor | PTGFR | Prostaglandin F | Prostanoid FP receptor
Type:
Enzyme
Mol. Mass.:
40072.29
Organism:
Homo sapiens (Human)
Description:
P43088
Residue:
359
Sequence:
MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
  
Inhibitor
Name:
BDBM523484
Synonyms:
(+/-)-5-{[(6-Bromo-3-chloro-2-phenylquinolin-4-yl)carbonyl]amino}-4-[2-(trifluoromethyl)phenyl]pentanoic Acid (Racemate) | US11136296, Example 215
Type:
Small organic molecule
Emp. Form.:
C28H21BrClF3N2O3
Mol. Mass.:
605.83
SMILES:
OC(=O)CCC(CNC(=O)c1c(Cl)c(nc2ccc(Br)cc12)-c1ccccc1)c1ccccc1C(F)(F)F
Structure:
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