Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 2
Ligand
BDBM523816
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
14.0±n/a nM
Citation
 Chen, B; Wei, X; Sun, X; Zhang, L; Xu, Z; Li, W; Zhang, P; Gao, F; Luo, Y; Li, J; Chen, S CXCR2 antagonist US Patent  US11136315 Publication Date 10/5/2021 
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Homo sapiens (Human)
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
  
Inhibitor
Name:
BDBM523816
Synonyms:
US11136315, Compound WX013A
Type:
Small organic molecule
Emp. Form.:
C20H24ClN3O5S
Mol. Mass.:
453.94
SMILES:
Oc1c(NC(=O)N[C@@H]2CCCc3ccoc23)ccc(Cl)c1S(=O)(=O)[C@H]1CCCNC1 |r|
Structure:
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