Reaction Details Report a problem with these data
Target
Glutathione reductase, mitochondrial
Ligand
BDBM524192
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
>100000±n/a nM
Citation
 Pelcman, B; Stafford, W Heterocyclylsulfonyl-substituted pyridines and their use in the treatment of cancer US Patent  US11168069 Publication Date 11/9/2021 
Target
Name:
Glutathione reductase, mitochondrial
Synonyms:
GLUR | GRD1 | GSHR_HUMAN | GSR | Glutathione reductase | Glutathione reductase (GR)
Type:
Enzyme
Mol. Mass.:
56271.52
Organism:
Homo sapiens (Human)
Description:
P00390
Residue:
522
Sequence:
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
  
Inhibitor
Name:
BDBM524192
Synonyms:
US11168069, Example 5
Type:
Small organic molecule
Emp. Form.:
C11H16N2O5S
Mol. Mass.:
288.32
SMILES:
COc1ccc(c(n1)S(=O)C1CCOCC1)N(O)=O
Structure:
Search PDB for entries with ligand similarity: