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Target
Dynamin-1-like protein
Ligand
BDBM524237
Substrate
n/a
Meas. Tech.
Drp1 Activity Screen
IC50
910±n/a nM
Citation
 Ji, N; Seenisamy, JN Dynamin-1-like protein inhibitors US Patent  US11168080 Publication Date 11/9/2021 
Target
Name:
Dynamin-1-like protein
Synonyms:
DLP1 | DNM1L | DNM1L_HUMAN | DRP1 | DVLP | Dnm1p/Vps1p-like protein | Dymple | Dynamin family member proline-rich carboxyl-terminal domain less | Dynamin-like protein | Dynamin-like protein 4 | Dynamin-like protein IV | Dynamin-related protein 1 | HdynIV
Type:
Protein
Mol. Mass.:
81878.71
Organism:
Human
Description:
O00429
Residue:
736
Sequence:
MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLILQLVHVSQEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEPSPAASAEADGKLIQDSRRETKNVASGGGGVGDGVQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW
  
Inhibitor
Name:
BDBM524237
Synonyms:
Preparation of N-(4-(1H-tetrazol-5-yl)phenyl)-4-methyl-1-((2-(piperidin-1-yl)thiazol-4-yl)methyl)-1H-pyrrole-2-carboxamide | US11168080, Compound A-7
Type:
Small organic molecule
Emp. Form.:
C22H24N8OS
Mol. Mass.:
448.544
SMILES:
Cc1cc(C(=O)Nc2ccc(cc2)-c2nn[nH]n2)n(Cc2csc(n2)N2CCCCC2)c1
Structure:
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