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Target
Dynamin-1-like protein
Ligand
BDBM524243
Substrate
n/a
Meas. Tech.
Drp1 Activity Screen
IC50
5500±n/a nM
Citation
 Ji, N; Seenisamy, JN Dynamin-1-like protein inhibitors US Patent  US11168080 Publication Date 11/9/2021 
Target
Name:
Dynamin-1-like protein
Synonyms:
DLP1 | DNM1L | DNM1L_HUMAN | DRP1 | DVLP | Dnm1p/Vps1p-like protein | Dymple | Dynamin family member proline-rich carboxyl-terminal domain less | Dynamin-like protein | Dynamin-like protein 4 | Dynamin-like protein IV | Dynamin-related protein 1 | HdynIV
Type:
Protein
Mol. Mass.:
81878.71
Organism:
Human
Description:
O00429
Residue:
736
Sequence:
MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLILQLVHVSQEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEPSPAASAEADGKLIQDSRRETKNVASGGGGVGDGVQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW
  
Inhibitor
Name:
BDBM524243
Synonyms:
Preparation of Methyl trans-4-(4-methyl-1-((2-(piperidin-1-yl)thiazol-4-yl)methyl)-1H-pyrrole-2-carboxamido)cyclohexane-1-carboxylate | US11168080, Compound A-13
Type:
Small organic molecule
Emp. Form.:
C22H30N4O3S
Mol. Mass.:
430.564
SMILES:
Cc1cc(C(=O)N[C@H]2CC[C@@H](CC2)C(O)=O)n(Cc2csc(n2)N2CCCCC2)c1 |r,wU:7.6,wD:10.13,(-2.51,-3.21,;-1.88,-1.8,;-2.65,-.47,;-1.62,.67,;-1.94,2.18,;-.79,3.21,;-3.4,2.66,;-4.55,1.63,;-4.23,.12,;-5.37,-.91,;-6.84,-.44,;-7.16,1.07,;-6.01,2.1,;-7.98,-1.47,;-7.66,-2.97,;-9.45,-.99,;-.21,.05,;1.12,.82,;2.46,.05,;2.46,-1.49,;3.92,-1.97,;4.83,-.72,;3.92,.52,;6.37,-.72,;7.14,-2.06,;8.68,-2.06,;9.45,-.72,;8.68,.61,;7.14,.61,;-.37,-1.48,)|
Structure:
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