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Target
Son of sevenless homolog 1 [564-1049]
Ligand
BDBM525053
Substrate
n/a
Meas. Tech.
Surface Plasmon Resonance (SPR) Assay
IC50
21.2±n/a nM
Citation
 Gill, AL; Buckl, A; Koltun, ES; Aay, N; Tambo-ong, AA; Thompson, S; Gliedt, MJ; Knox, JE; Cregg, J; Edwards, AV; Liu, Y; Burnett, GL Bicyclic heteroaryl compounds and uses thereof US Patent  US11168102 Publication Date 11/9/2021 
Target
Name:
Son of sevenless homolog 1 [564-1049]
Synonyms:
SOS1 | SOS1_HUMAN | Son of sevenless homolog 1 (SOS1)(564-1049)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
56970.22
Organism:
n/a
Description:
aa 564-1049
Residue:
486
Sequence:
EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT
 
Inhibitor
Name:
BDBM525053
Synonyms:
US11168102, Example 8-2.
Type:
Small organic molecule
Emp. Form.:
C24H28F3N5O
Mol. Mass.:
459.5072
SMILES:
C[C@@H](Nc1nc(C)nc2n(C)c(=O)c(cc12)C1CCN(C)CC1)c1cccc(C(F)F)c1F |r|
Structure:
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